Gene information
Official symbol FGB
Official full name fibrinogen beta chain
Gene type protein-coding gene
Chromosome4q31.3
Gene familyReceptor ligands; Fibrinogen C domain containing
Resources
Entrez Gene 2244
HGNC HGNC:3662
Ensembl ENSG00000171564
Vega OTTHUMG00000150331
UCSC uc003ioa.5
GO terms: 125 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0005198 structural molecule activity GO Molecular Functions -7.51921139 30 More
GO:0005201 extracellular matrix structural constituent GO Molecular Functions -12.8379048 20 More
GO:0005577 fibrinogen complex GO Cellular Components -9.87912674 6 More
GO:0005938 cell cortex GO Cellular Components -2.49954036 24 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007160 cell-matrix adhesion GO Biological Processes -9.58867374 15 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010769 regulation of cell morphogenesis involved in differentiation GO Biological Processes -2.23849437 5 More
GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO Biological Processes -2.60117175 5 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010811 positive regulation of cell-substrate adhesion GO Biological Processes -6.61578697 11 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0017157 regulation of exocytosis GO Biological Processes -7.48561663 15 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0019731 antibacterial humoral response GO Biological Processes -4.08950781 6 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0031639 plasminogen activation GO Biological Processes -7.61185031 7 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0034109 homotypic cell-cell adhesion GO Biological Processes -7.07578331 9 More
GO:0034114 regulation of heterotypic cell-cell adhesion GO Biological Processes -12.8696023 10 More
GO:0034116 positive regulation of heterotypic cell-cell adhesion GO Biological Processes -9.73495436 7 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042730 fibrinolysis GO Biological Processes -16.7830831 11 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044321 response to leptin GO Biological Processes -5.08699974 5 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045907 positive regulation of vasoconstriction GO Biological Processes -14.7401025 12 More
GO:0045921 positive regulation of exocytosis GO Biological Processes -5.75584660 9 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051087 chaperone binding GO Molecular Functions -6.81600949 11 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051592 response to calcium ion GO Biological Processes -7.43492702 23 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070527 platelet aggregation GO Biological Processes -8.40921139 9 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0072376 protein activation cascade GO Biological Processes -12.3481888 9 More
GO:0072378 blood coagulation, fibrin clot formation GO Biological Processes -12.9665312 9 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:1900024 regulation of substrate adhesion-dependent cell spreading GO Biological Processes -3.01391737 5 More
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO Biological Processes -2.81707928 4 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -8.64891123 8 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904036 negative regulation of epithelial cell apoptotic process GO Biological Processes -12.0631217 12 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2000352 negative regulation of endothelial cell apoptotic process GO Biological Processes -10.8868003 10 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
Drug-Gene interaction
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Related drugs: 7 records
Related studies: 59 records
Molecular factor Omics type Application Objective MI type Reference
NM_005141.5:c.-455G>A genomics fibrinogen[other] acute myocardial infarction Green F et al. Thromb Haemost. 1993
NM_005141.5:c.17382G>T genomics myocardial infarction[diagnosis] myocardial infarction Yu Q et al. J Investig Med. 1996
NM_005141.5:c.1433G>A genomics coronary artery stenosis[prognosis (bad)] myocardial infarction French JK et al. Am Heart J. 2003
NM_005141.5:c.-148C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Sampaio MF et al. Clin Chim Acta. 2007
NM_005141.5:c.1433G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Lu XF et al. Chin Med J (Engl). 2008
NM_005141.5:c.-455G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Rallidis LS et al. Thromb Res. 2010
NM_005141.5:c.-455G>A genomics myocardial infarction[diagnosis] myocardial infarction Qi L et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012
NM_005141.5:c.-455G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction El-Fattah AAA et al. Gene. 2018
NM_005141.5:c.[-455G>A;1433G>A;8558C>G] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Lu XF et al. Chin Med J (Engl). 2008
FGB_BclI genomics acute myocardial infarction[diagnosis] acute myocardial infarction Zito F et al. Arterioscler Thromb Vasc Biol. 1997
FGB_BclI genomics myocardial infarction[diagnosis] myocardial infarction Zito F et al. Thromb Haemost. 1999
fibrinogen proteomics left ventricular thrombus[prognosis (bad)] acute myocardial infarction Perdigao C et al. Rev Port Cardiol. 1992
fibrinogen proteomics coronary artery patency[prognosis (good)] acute ST elevation myocardial infarction Ostermann H et al. Eur Heart J. 1992
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Kelleher CC et al. Atherosclerosis. 1992
fibrinogen proteomics thrombolytic agent[treatment (pharmacotherapy)] acute myocardial infarction Maly J et al. Vnitr Lek. 1991
fibrinogen proteomics hemorrhage[prognosis (bad)] acute ST elevation myocardial infarction Arnold AE et al. J Am Coll Cardiol. 1989
fibrinogen proteomics old myocardial infarction[diagnosis] old myocardial infarction Berglund U et al. Thromb Haemost. 1988
fibrinogen proteomics myocardial reperfusion[prognosis (good)] acute ST elevation myocardial infarction Lew AS et al. Am J Cardiol. 1986
fibrinogen proteomics old myocardial infarction[diagnosis] old myocardial infarction Muscari A et al. Cardiology. 1995
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Bara L et al. Thromb Haemost. 1994
fibrinogen proteomics streptokinase[treatment (pharmacotherapy)] acute myocardial infarction Salvioni A et al. Eur Heart J. 1994
fibrinogen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Moreno JA et al. Sangre (Barc). 1994
fibrinogen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Bobins M et al. Pol Arch Med Wewn. 1996
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Sato S et al. J Epidemiol. 1996
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Carter AM et al. Circulation. 1998
fibrinogen proteomics alteplase[treatment (pharmacotherapy)] acute myocardial infarction Tousoulis D et al. Am J Cardiol. 1998
fibrinogen proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tousoulis D et al. Am J Cardiol. 1998
fibrinogen proteomics old myocardial infarction[diagnosis] old myocardial infarction Danielsen R et al. Scand Cardiovasc J. 1998
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Freeburn JC et al. Br J Haematol. 1998
fibrinogen proteomics cardiorenal syndrome type 1[prognosis (bad)] myocardial infarction Scarabin PY et al. Thromb Haemost. 1998
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Ma J et al. J Am Coll Cardiol. 1999
fibrinogen proteomics ischemic cardiac events[prognosis (bad)] acute ST elevation myocardial infarction Reganon E et al. Thromb Haemost. 1999
fibrinogen proteomics arteriosclerosis[prognosis (bad)] myocardial infarction Tataru MC et al. Coron Artery Dis. 2001
fibrinogen proteomics arteriosclerosis[prognosis (bad)] myocardial infarction Tataru MC et al. Coron Artery Dis. 2001
fibrinogen proteomics cardiovascular death[prognosis (bad)] old myocardial infarction Retterstol L et al. J Intern Med. 2001
fibrinogen proteomics infarct size[other] acute ST elevation myocardial infarction De Sutter J et al. Atherosclerosis. 2001
fibrinogen proteomics old myocardial infarction[diagnosis] old myocardial infarction Lowe GD et al. J Thromb Haemost. 2003
fibrinogen proteomics old myocardial infarction[diagnosis] old myocardial infarction Mannila MN et al. Thromb Haemost. 2004
fibrinogen proteomics death[prognosis (bad)] acute myocardial infarction Coppola G et al. Ital Heart J. 2005
fibrinogen proteomics complication[prognosis (bad)] acute ST elevation myocardial infarction Ziakas A et al. Angiology. 2006
fibrinogen proteomics no-reflow phenomenon[prognosis (bad)] acute ST elevation myocardial infarction Wasilewski J et al. Kardiol Pol. 2006
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Jaeger CP et al. Arq Bras Cardiol. 2006
fibrinogen proteomics poor predictor major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Ketch TR et al. Am Heart J. 2008
fibrinogen proteomics coronary artery stenosis[prognosis (bad)] acute myocardial infarction Tatli E et al. Cardiol J. 2009
fibrinogen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Shojaie M et al. Vasc Health Risk Manag. 2009
fibrinogen proteomics left ventricular thrombus[prognosis (bad)] acute anterior ST elevation myocardial infarction Shacham Y et al. Am J Cardiol. 2013
fibrinogen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Habib SS et al. J Pak Med Assoc. 2012
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Vishwajeet V et al. Acta Cardiol. 2018
fibrinogen proteomics poor predictor coronary artery stenosis[prognosis (bad)] myocardial infarction Gao XY et al. Oncotarget. 2017
fibrinogen proteomics atorvastatin plus bivalirudin[treatment (pharmacotherapy)] acute myocardial infarction Dong SH et al. Ann Palliat Med. 2020
fibrinogen beta chain proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dinerman JL et al. J Am Coll Cardiol. 1990
NM_005141.5:c.-249C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Barsova RM et al. PLoS One. 2015
fibrinogen proteomics thrombosis[prognosis (bad)] acute anterior myocardial infarction Dempfle CE et al. Thromb Haemost. 1999
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Leander K et al. J Intern Med. 2002
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Nordestgaard BG et al. Clin Chem. 2010
fibrinogen proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Yunyun W et al. BMC Cardiovasc Disord. 2014
fibrinogen proteomics poor predictor left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Reindl M et al. Eur Heart J Acute Cardiovasc Care. 2017
fibrinogen proteomics poor predictor reduced left ventricular ejection fraction[prognosis (bad)] acute ST elevation myocardial infarction Reindl M et al. Eur Heart J Acute Cardiovasc Care. 2017
fibrinogen proteomics myocardial infarction[diagnosis] myocardial infarction Pletsch-Borba L et al. Sci Rep. 2019
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